St Jude device lowers blood pressure in small study

(Reuters) – St Jude Medical Inc said on Monday its procedure that deadens nerves near the kidneys helped lower blood pressure in a small study of patients whose hypertension could not be controlled with drugs.

Patients in the study who were treated with the Enlightn renal denervation system saw an average reduction of 28 points in systolic blood pressure, which is the first number expressed in a reading, after 30 days. At six months, the 46 patients who received the treatment maintained an average systolic blood pressure reduction of 26 mmHg points.

The results were presented at the annual meeting of the American Heart Association in Los Angeles.

Patients enrolled in the study had an average blood pressure of 176/96 mmHg despite being treated with multiple medications to manage the condition. No serious side effects were reported, St Jude said.

Normal blood pressure is below 120/80 mmHg. Hypertension, or high blood pressure, is a reading above 140/90 mmHg.

Renal denervation is a procedure in which a thin, flexible catheter is threaded through the body to the renal sympathetic nerves near the kidneys. Radiofrequency energy is delivered to disrupt the nerve activity, relieving high blood pressure.

Millions of people have hypertension that is resistant to drugs, putting them at risk of heart attacks and stroke.

The new therapy is not yet approved in the United States, but several products are already available in Europe.

Device makers that have already received approval to sell hypertension devices in Europe include Medtronic, the front-runner, St Jude, Covidien, ReCor Medical and Vessix Vascular.

St Jude shares were up 29 cents, or less than 1 percent, at $ 38.80 in afternoon trading on the New York Stock Exchange.

(Reporting By Susan Kelly and Debra Sherman in Chicago; Editing by Gerald E. McCormick, Leslie Adler and Jim Marshall)

Medications/Drugs News Headlines – Yahoo! News

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The Romney message: It’s no longer just the economy, stupid

Romney reflected his in TelePrompter at a Virginia rally (Justin Sullivan/Getty Images)

ENGLEWOOD, Colo.—Four years ago, Mitt Romney was criticized as a man without a message, a presidential candidate straight from the heart of corporate America who was good at making lists and delivering PowerPoint presentations but not so great at explaining exactly why he should be the next president.

His initial slogan in 2008—"True Strength for America's Future"—was vague. And his push to focus on "innovation and transformation"—which advisers back then initially claimed as his chief focus—fell flat. To make up ground, Romney moved to the right, running away from his record as a moderate—a push that earned him a reputation as a phony that doomed his first bid for the Republican nomination.

But as Romney nears the end of his second campaign for the White House, there has been no mistaking the core argument for his candidacy. Speaking this weekend to a crowd of 17,000 people in this battleground district in a swing state, Romney used the word "change" no less than a dozen times—arguing that, if elected, he would bring "real change" and "big change."

"The question of this election comes down to this: do you want more of the same or do you want real change?" Romney said, speaking against the backdrop of an enormous sign that read "Real Change on Day One."

"President Obama promised change, but he could not deliver it," Romney said. "I promise change, and I have a record of achieving it."

To hear Romney on the stump over the past few weeks has been to experience a flashback of Barack Obama's 2008 campaign. At virtually every stop, the Republican presidential nominee has spoken of the need for a "new beginning" and of the "movement" he's leading toward the White House. He's transformed a stump speech that four years ago was heavy on lists of talking points on at least a dozen policies into something not unlike a motivational speech. Romney has become a storyteller, talking about the people he's met on his long road to the presidency or the people he's helped in his personal life. He tries to sell voters on his vision of the future, describing the election as a quest for "American greatness" and the desire for a "better tomorrow."

"Obama had his moment, and he's offered 'more of the same,'" Stuart Stevens, Romney's chief strategist, told Yahoo News, using a phrase that James Carville made famous as one of the three core messages of Bill Clinton's 1992 presidential campaign: "It's the economy, stupid"; "change versus more of the same"; and "don't forget health care."

The Romney campaign has in essence landed on the same message: the economy, change, and don't forget Obamacare.

"This is our moment," Stevens said," and we think people want something different than the last four years."

Romney's embrace of the "change" argument seems to have driven his rise in the polls in recent weeks, but it comes after months of what many Republicans criticized as a muddled message. For much of 2012, his campaign focused almost exclusively on the economy—arguing it would be the ultimate deciding factor of the election. Asked about other issues, including subjects like abortion or the wars in Iraq and Afghanistan, Romney often would often use the question to pivot back to his argument that he would be the best-positioned candidate to create jobs and get the economy back on track. Romney strayed from his economic message only a few times—mostly in the Republican primary when he fought off challenges from Rick Santorum and Newt Gingrich by arguing that he had been a "severely conservative" governor of Massachusetts.

But in keeping his focus on the economy, Romney downplayed what many considered his biggest strength in the race—his experience as a corporate turnaround artist at Bain Capital. The move allowed the Obama campaign and its Democratic allies to turn Romney's Bain experience into one of his greatest vulnerabilities, casting the candidate as a coldblooded corporate type willing to ship American jobs overseas if it was better for the bottom line.

The attacks sent Romney's favorability numbers plummeting—and prompted anxiety within the campaign that he might not recover. Romney aides continue to defend the campaign's slow response, insisting it simply didn't have the money to run ads responding to the attacks.

But many insiders also point fingers to the candidate, himself, who was initially reluctant to talk about his Bain experience or defend himself against Democratic attacks on his personal wealth.

"Believe it or not, Mitt actually is a modest guy," a longtime Romney adviser tells Yahoo News. "He doesn't like talking about his money. And I think he thought the Bain stuff would blow over. He thought it was a silly issue compared to 23 million unemployed and all of the other negatives of the Obama economy. … I think a lot of us did. He was wrong, and we were wrong."

Yet on stage in recent weeks, Romney seems to have finally found his voice on the issue, delivering a simple and straightforward explanation of his resume.

"I built a business, and turned around another," Romney said at an appearance outside Milwaukee last week. "I helped put an Olympics back on track. And with a Democratic legislature, I helped turn my state from deficit to surplus, from job losses to job growth, and from higher taxes to higher take-home pay. This is why I am running for president. I know how to change the course the nation is on, how to get us to a balanced budget and how to build jobs and rising take-home pay."

A longtime Republican consultant close to the Romney campaign privately questioned why the candidate wasn't making this "simpler argument" earlier in the campaign. "If the Romney people have been seeing out there in the past few days would have shown up over the summer, this race might not be so close," the consultant, who declined to be named, told Yahoo News.

But other Romney aides argue that the candidate first needed to show his "real" side to voters--something his campaign could not afford to do until after the Republican convention.

"The message that works so well does so in part because the electorate finally has a sense of who he really is. Now that they do, the message and the messenger are integrated," Tom Rath, a New Hampshire political consultant and a longtime Romney adviser, told Yahoo News.  "It is a great message, one that we always believed could win, but one that could only work when the voters felt they knew him well enough to make it credible."

In recent weeks, Romney has sounded a centrist tone, vowing to work with lawmakers "on both sides of the aisle who care more about country than politics." Obama is too politically radioactive to overcome the partisan gridlock of Washington," Romney regularly says.

"He will be unable to work with the people in Congress," he says. "He has ignored them, attacked them, blamed them. … The president was right when he said he can't change Washington from the inside. … You can take him at his word."

Stuart Stevens insists Romney's latest message isn't much different than speeches he gave early in his campaign—though Stevens acknowledges the phrase "change" wasn't as prominent.

"Campaigns aren't static, otherwise no one would listen to you," Stevens told Yahoo News. But, he added, Obama gave Romney an opportunity to play the "change" card by not presenting a clearer picture of what he would do with a second term.

"That was a huge opportunity for us," Stevens said. "It allowed us to present the contrast between us and them … In a campaign, you have different moments to say different things.

Inside the campaign, aides view Romney as an agent of change not unlike Obama four years ago. They admit Romney will never inspire crowds like Obama did in '08, but in an argument Romney hopes will decide the election, they contend he can deliver on the change Obama promised to bring to Washington.

"Change is not a message that Barack Obama invented," Stevens said. "It's a message that he co-opted … and a message he didn't deliver on. And Mitt Romney can."

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Bomb shakes Damascus, opposition holds unity talks

AMMAN (Reuters) – A bomb exploded near army and security compounds in Damascus, Syrian television reported, and fractured opposition groups seeking to topple President Bashar al-Assad began unity talks abroad to win international respect and arms supplies.

The 50-kilogram (110-pound) bomb, near a large hotel in a heavily guarded district, was described by state media as an attack by “terrorists” – the government’s term for insurgents in the 19-month-old uprising against Assad.

Opposition activists said Sunday’s blast appeared to be the work of the Ahfad al-Rasoul (Grandsons of the Prophet) Brigade, an Islamist militant unit that attacked military and intelligence targets several times in the last two months.

The mainly Sunni rebels have carried out a series of bombings targeting government and military buildings in Damascus this year, extending the war into the seat of Assad’s power.

The Syrian conflict has aggravated divisions in the Islamic world, with Shi’ite Iran supporting Assad — whose Alawite faith derives from Shi’ite Islam — and U.S.-allied Sunni nations such as Saudi Arabia, Turkey and Qatar backing his foes.

The Syrian Network for Human Rights, an activist monitoring group, said government forces had killed 179 people on Sunday. It said most of the dead were civilians killed in shelling of Damascus suburbs and included 14 women and 20 children. The rest were rebels killed in battles in the capital and the northern provinces of Idlib and Aleppo.

Opposition campaigners said the Syrian army shelled rebel positions inside a Palestinian refugee camp on the edge of Damascus on Sunday, killing at least 20 people. They said the Yarmouk camp had become the latest battleground in the war.

In northern Idlib, opposition sources said rebels were forced to halt an offensive to take a big air base because of a shortage of ammunition, a problem that has dogged their campaign to cement a hold on the north by eliminating Assad’s devastating edge in firepower.

Islamist insurgents had launched the attack on the Taftanaz military airport at dawn on Saturday, using rocket launchers and at least three tanks captured from the military.

The Syrian government restricts journalists’ access in Syria, making it difficult to verify reports from the ground.

The Jaafar bin Tayyar Division, a rebel unit in Deir al-Zor, said its fighters had taken control of the al-Ward oilfield near the Iraqi border on Sunday, after overrunning a loyalist outpost that had 40 militiamen defending it.

Rebel commanders, former Syrian officials and the Syrian head of an oil services company familiar with oil production in the area said the fields, mostly not operational, had been under de facto rebel control for months.

FEARS OF WIDER CONFLAGRATION

The conflict began with peaceful protest rallies that morphed into armed revolt when Assad, whose family has ruled Syria since 1971, tried to stamp them out with military might. About 32,000 people have been killed, wide swathes of the major Arab state have been wrecked and the civil war threatens to widen into a regional sectarian conflagration.

The opposition talks that began in Qatar marked the first concerted attempt to meld feuding, disparate groups based abroad and coordinate strategy with rebels fighting in Syria.

Divisions between Islamists and secularists as well as between those inside Syria and opposition figures based abroad have foiled prior attempts to forge a united opposition and deterred Western powers from intervening militarily.

Analysts were skeptical the planned four days of opposition talks in the Qatari capital Doha would bring immediate results.

They aim to broaden the Syrian National Council (SNC), the largest of the overseas-based opposition groups, from some 300 members to 400, to pave the way for talks in Doha on Thursday including other anti-Assad factions to crystallise a coalition.

“The main aim is to expand the council to include more of the social and political components. There will be new forces in the SNC,” Abdulbaset Sieda, current leader of the Syrian National Council, told reporters in Doha ahead of the meeting.

The meetings would also elect a new executive committee and leader for the SNC, he said.

A Qatar-based security analyst, who asked not to be named, said the meetings would bring a small step forward, at most. “The Syrian National Council is just too divided,” he said.

In Cairo, the international mediator on Syria, Lakhdar Brahimi, called on Sunday for world powers to issue a U.N. Security Council resolution based on a deal they reached in June to set up a transitional Syrian government.

But Russian Foreign Minister Sergei Lavrov, speaking at the same news conference, dismissed the need for a resolution and said others were stoking violence by backing rebels. His comments highlighted the impasse over Syria’s civil war.

Russia and China, both permanent council members, have vetoed three Western-backed U.N. draft resolutions condemning Assad’s government for the violence. The other three permanent members are the United States, Britain and France.

(Additional reporting by Rania el Gamal and Regan Doherty in Qatar, Suleiman al-Khalidi in Amman; Editing by Philippa Fletcher and Stephen Powell)

World News Headlines – Yahoo! News

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Sharon Osbourne has double mastectomy

LONDON (AP) — Sharon Osbourne says she had a double mastectomy after learning she carries a gene that increases the risk of developing breast cancer.

Osbourne told Hello! magazine that “I didn’t want to live the rest of my life with that shadow hanging over me.”

The 60-year-old “America’s Got Talent” judge, who had colon cancer a decade ago, said that without the surgery, “the odds are not in my favor.”

She added: “It’s not ‘pity me,’ it’s a decision I made that’s got rid of this weight that I was carrying around.”

The magazine went on sale Monday.

Osbourne, husband Ozzy and children Jack and Kelly became rock’s most famous clan thanks to reality show “The Osbournes” a decade ago.

Jack Osbourne, 26, was recently diagnosed with multiple sclerosis.

Entertainment News Headlines – Yahoo! News

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Microsoft CEO expects volumes on Windows Phone to "ramp quickly"

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BioMarin genetic disorder drug meets main goal, shares jump

(Reuters) – BioMarin Pharmaceutical Inc said a late-stage trial of its experimental genetic disorder drug met the main goal of improving patients’ walking ability when administered weekly, sending the company‘s shares up 25 percent in premarket trading.

The drug, called GALNS, however, did not show any improvement over a placebo when administered every other week.

The trial, named MOR-004, showed that weekly doses of the drug at 2 mg/kg improved the six-minute walk distance of patients by 22.5 meters over the placebo.

However, patients getting the same dose every other week did not show any meaningful or statistically significant change compared to the placebo.

The disorder – Mucopolysaccharidosis Type IVA (MPS IVA), or Morquio A Syndrome – is a rare, inherited disorder caused by the deficiency of a particular enzyme, leading to skeletal dysplasia, short stature and joint abnormalities.

The drug was also tested in another extension trial that showed its benefits continued to improve with further dosage, BioMarin said in a statement.

GALNS was generally well-tolerated and adverse events were similar to those seen in the trials of other enzyme replacement therapies. There were no deaths and no patients withdrew from the study due to adverse events.

BioMarin now plans to submit marketing applications for the drug, starting from the first quarter of 2013.

The company currently has four drugs in the market, two of which are for treating other metabolic disorders caused by the absence of certain enzymes.

Shares of the company closed at $ 37.41 on the Nasdaq on Friday, and were trading at $ 47 before markets opened on Monday. (Reporting by Esha Dey in Bangalore; Editing by Joyjeet Das)

Medications/Drugs News Headlines – Yahoo! News

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Will it all come down to Ohio? Both campaigns focus on the state

Most Memorable 2012 Campaign Moments http://t.co/hOTxtWMO

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Brazil’s ‘pop-star priest’ gets mammoth new stage

SAO PAULO (AP) — Brazil‘s “pop-star priest” is already packing in the crowds at the newly opened mammoth sanctuary that he built for his campaign to stem the exodus of faithful from the Roman Catholic Church in Latin America’s biggest nation.

Brazil still has more Catholics than any other country in the world, with about 65 percent of its 192 million people identifying themselves that way in the 2010 census. But that is down from 74 percent in 2000 and is the lowest since records began tracking religion 140 years ago.

That’s where Father Marcelo Rossi‘s Mother of God sanctuary comes in. The not-yet-finished structure will seat 6,000 people and have standing room for 14,000 more, church leaders say. In addition, the grounds outside can hold 80,000 people who could watch Mass on outdoor video screens.

After the inaugural Mass on Friday attracted upward of 50,000 people, a beaming Rossi told reporters: “They couldn’t all fit in. There was a crowd that had to stand outside! That’s a sign we’re on the right path, and it’s this sanctuary.”

Similar numbers jammed into the huge church Saturday.

It’s a fitting stage for Rossi, a Latin Grammy-nominated singer who is known for tossing buckets of holy water on worshippers and performing rollicking Christian songs backed by a blasting live band during Mass.

The church sits on 323,000 square feet (30,000 square meters) of land. Church officials declined to confirm how big the actual building is, though local reports put it at 91,500 square feet (8,500 square meters). That would make it one of the world’s 10 biggest churches. A cross soaring 138 feet (42 meters) into the air is the focal point.

The Mother of God sanctuary is anything but traditional. Designed by noted Brazilian architect Ruy Ohtake, it has a wide-open layout giving it the feel of a warehouse. Concrete walls hold up a sloping blue roof that from the outside looks more like a basketball arena than a house of worship. With the church several years away from completion, white plastic chairs were in the place of pews for a lucky few thousand to grab a seat. The rest had to stand.

Rossi dismisses the idea his huge church is a response to the explosion of the evangelical Christian faith in Brazil. Rather, the priest seems to be battling what recent studies indicate is Catholicism’s biggest enemy: indifference.

While millions of Brazilian Catholics joined Pentecostal congregations in the 1990s, a study conducted last year by Brazil’s Getulio Vargas Foundation based on census data found that the Catholics leaving the church these days are mostly becoming nonreligious. Experts have said the trend of Brazilians deciding organized religion isn’t for them poses a more potent threat to Catholic leaders than losses to the Pentecostals.

Rossi chose to open his new church on the Brazilian holiday of Finados, the nation’s version of the Day of the Dead. “A day, a day that was dead, was transformed!” the priest told worshippers during the service, using his gold-plated microphone.

The “pop-star priest” is seen by Brazilian Catholicism as its biggest weapon against the lack of interest, and his new sanctuary adds to his tools of best-selling books and music recordings to keep worshippers interested in what many complain has become a staid institution.

There was nothing stale about his Mass on Friday.

Singing as loud as they could, waving white hankies and swaying with a rocking band, the 20,000 people who jammed into the Mother of God sanctuary hammed it up for TV cameras and shed tears down their cheeks as their superstar priest waved to them from the pulpit. An estimated 30,000 other people had gathered outside, where young boys climbed up into nearby trees trying to get a glimpse of the church grounds as they squinted over a sea of heads streaming out of the sanctuary.

“We have problems, everyone has problems,” worshipper Zuleima de Oliveira Sales said as she stood in the tightly packed sea of people under the soaring blue roof of the structure, her voice choking. “They don’t come to an end, but I have faith, I have faith in Our Lady.”

That’s the sort of belief the Catholic Church is counting on in Brazil and other developing nations. Leaders from the Vatican on down are looking to them as bulwarks against losses in Europe and the U.S., where sex abuse scandals have inspired many people to leave the church. About half of the world’s Catholics live in Latin America.

Pentecostalism was once seen as a major threat to Brazil’s Catholic Church. Pentecostal churches, many of them founded by U.S. evangelicals, saw their membership double to more than 12 percent of the country’s population over the 1990s, with about half of the congregants estimated to be former Catholics.

During the 1990s, Brazil’s economy suffered from hyperinflation and other woes, and Pentecostal churches aggressively recruited in the slums and poor outskirts of Brazil’s cities by offering nuts-and-bolts self-improvement advice as well as Christian ministry.

Since 2003, however, Pentecostal churches have seen growth slow. The percentage of Brazilians calling themselves Pentecostals edged up from 12.5 percent of the population to 13.3 percent.

Yet the Catholic Church has continued to lose parishioners, and church leaders have had little success so far in halting that trend.

Brazil was the first nation outside Europe that Pope Benedict XVI visited, during a five-day tour in 2007 largely aimed at stopping losses in Latin America. During the trip, the pope canonized Brazil’s first native-born saint.

Then Benedict announced last August during the church’s World Youth Day, which drew 1.5 million people to Spain, that the next version of the gathering would be held in Rio de Janeiro in 2013. The pope is expected to attend.

For now, Rossi hopes his big church will bring together tens of thousands of faithful for every Mass, giving new energy to the Catholic faith.

“People want big spaces. They want grand places for prayer,” he told the Globo TV network. “One candle illuminates, 10 candles illuminate — and 100,000 candles light up so much more.”

Latin America News Headlines – Yahoo! News

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AnnaLynne McCord to get “Scorned” With Billy Zane in new thriller

LOS ANGELES (TheWrap.com) – AnnaLynne McCord is about to become a woman “Scorned.”

“90210″ star McCord has signed on for the revenge thriller “Scorned,” alongside “Titanic” star Billy Zane and Viva Bianca from Starz’s “Spartacus.”

McCord and Zane will play Sadie and Kevin, a couple whose romantic weekend at a lake house takes a sideways turn when a text message from Sadie’s best friend (played by “Bianca”) to Kevin reveals a lurid love affair between the two, sending Sadie on a vengeance spree.

“Scorned” will be directed by Mark Jones, the creator and director of the beloved “Leprechaun” horror-movie series.

Jones likened the project to “sophisticated” thrillers such as “Fatal Attraction” and “Misery.”

“Having done horror with comedy, I wanted to delve into something more sophisticated along the lines of ‘Fatal Attraction’ and ‘Misery,’ and develop a multi-dimensional, twisted character in our lead villain (McCord), who I feel brings an original and incredibly unique take on her character,” Jones said.

Lightning Entertainment will handle international sales of the film, with Lightning’s Audrey Delaney and Marc Bienstock executive-producing.

Movies News Headlines – Yahoo! News

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Google's Android software in 3 out of 4 smartphones

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